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1

Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases

Whitaker, Ryan M., Corum, Daniel, Beeson, Craig C., Schnellmann, Rick G.

Journal:

Annual Review of Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.01 MB

english, 2016

2

T HE R OLE OF C ALPAIN IN O NCOTIC C ELL D EATH

Liu, Xiuli, Van Vleet, Terry, Schnellmann, Rick G.

Journal:

Annual Review of Pharmacology

Year:

2004

Language:

english

File:

PDF, 263 KB

english, 2004

3

High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury

Wills, Lauren P., Beeson, Gyda C., Trager, Richard E., Lindsey, Christopher C., Beeson, Craig C., Peterson, Yuri K., Schnellmann, Rick G.

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.02 MB

english, 2013

4

Quantitative analysis of mitochondrial morphology and membrane potential in living cells using high-content imaging, machine learning, and morphological binning

Leonard, Anthony P., Cameron, Robert B., Speiser, Jaime L., Wolf, Bethany J., Peterson, Yuri K., Schnellmann, Rick G., Beeson, Craig C., Rohrer, Bärbel

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2015

Language:

english

File:

PDF, 2.22 MB

english, 2015

5

Mitochondrial energetics in the kidney

Bhargava, Pallavi, Schnellmann, Rick G.

Journal:

Nature Reviews Nephrology (formerly Nature Clinical Practice Nephrology)

Year:

2017

Language:

english

File:

PDF, 863 KB

english, 2017

6

Transforming growth factor-β1 inhibits regeneration of renal proximal tubular cells after oxidant exposure

Sandra E. Kays, Grazyna Nowak, Rick G. Schnellmann

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

1996

Language:

english

File:

PDF, 525 KB

english, 1996

7

The in vitro metabolism and bioactivation of 1,2-dibromoethane (ethylene dibromide) by human liver

David A. Wiersma, Rick G. Schnellmann, I. Glenn Sipes

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

1986

Language:

english

File:

PDF, 610 KB

english, 1986

8

The effects of haloalkene cysteine conjugates on cytosolic free calcium levels in suspensions of rat renal proximal tubules

Carlotta E. Groves, Edward A. Lock, Rick G. Schnellmann

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

1990

Language:

english

File:

PDF, 577 KB

english, 1990

9

Pentachlorobutadienyl-l-cysteine (PCBC) toxicity: The importance of mitochondrial dysfunction

Dr. Carlotta E. Groves, Rick G. Schnellmann, Dr. Paul P. Sokol, Thomas G. Steffens, Edward A. Lock

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

1991

Language:

english

File:

PDF, 759 KB

english, 1991

10

Intracellular calcium chelators and oxidant-induced renal proximal tubule cell death

Rick G. Schnellmann

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

1991

Language:

english

File:

PDF, 308 KB

english, 1991

11

Differential cellular effects in the toxicity of haloalkene and haloalkane cysteine conjugates to rabbit renal proximal tubules

Carlotta E. Groves, Rick G. Schnellmann, Patrick J. Hayden, Edward A. Lock

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

1993

Language:

english

File:

PDF, 794 KB

english, 1993

12

Arachidonic acid release in renal proximal tubule cell injuries and death

Rick G. Schnellmann, Xiaonian Yang, Joan B. Carrick

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

1994

Language:

english

File:

PDF, 667 KB

english, 1994

13

Toll-like receptor 4 is a key mediator of murine steatotic liver warm ischemia/reperfusion injury

Justin D. Ellett, Zachary P. Evans, Carl Atkinson, Michael G. Schmidt, Rick G. Schnellmann, Kenneth D. Chavin

Journal:

Liver Transplantation

Year:

2009

Language:

english

File:

PDF, 269 KB

english, 2009

14

Toll-like receptor 4 knockout mice are protected from endothelial overactivation in the absence of Kupffer cells after total hepatic ischemia/reperfusion

Justin D. Ellett, Carl Atkinson, Zachary P. Evans, Zainab Amani, Edward Balish, Michael G. Schmidt, Rick G. Schnellmann, Kenneth D. Chavin

Journal:

Liver Transplantation

Year:

2011

Language:

english

File:

PDF, 2.07 MB

english, 2011

15

Hepatic mixed function oxygenase activity and glutathione S-transferase activity in mice following ethanol consumption and withdrawal

Rick G. Schnellmann, David A. Wiersma, Debra J. Randall, Thomas L. Smith, I.Glenn Sipes

Journal:

Year:

1984

Language:

english

File:

PDF, 708 KB

english, 1984

16

A high-throughput respirometric assay for mitochondrial biogenesis and toxicity

Craig C. Beeson, Gyda C. Beeson, Rick G. Schnellmann

Journal:

Analytical Biochemistry

Year:

2010

Language:

english

File:

PDF, 879 KB

english, 2010

17

Caspase-dependent and -independent induction of phosphatidylserine externalization during apoptosis in human renal carcinoma Cak1-1 and A-498 cells

Edward A. Lock, Celia J. Reed, Gilbert R. Kinsey, Rick G. Schnellmann

Journal:

Year:

2007

Language:

english

File:

PDF, 1010 KB

english, 2007

18

Lack of formic acid production in rat hepatocytes and human renal proximal tubule cells exposed to chloral hydrate or trichloroacetic acid

Edward A. Lock, Celia J. Reed, JoEllyn M. McMillan, John E. Oatis Jr., Rick G. Schnellmann

Journal:

Year:

2007

Language:

english

File:

PDF, 803 KB

english, 2007

19

Multiple effects of presumed glutathione depletors on rabbit proximal tubules

Schnellmann, Rick G, Mandel, Lazaro J

Journal:

Kidney International

Year:

1986

Language:

english

File:

PDF, 485 KB

english, 1986

20

Intracellular distribution and depletion of glutathione in rabbit renal proximal tubules

Schnellmann, Rick G, Gilchrist, Siobhan M, Mandel, Lazaro J

Journal:

Kidney International

Year:

1988

Language:

english

File:

PDF, 482 KB

english, 1988

21

Cytotoxicity of Linoleic Acid Diols to Renal Proximal Tubular Cells

Jeffery H. Moran, Rick Weise, Rick G. Schnellmann, J.P. Freeman, David F. Grant

Journal:

Toxicology and Applied Pharmacology

Year:

1997

Language:

english

File:

PDF, 140 KB

english, 1997

22

Renal Cell Regeneration Following Oxidant Exposure: Inhibition by TGF-β1and Stimulation by Ascorbic Acid

Grażyna Nowak, Rick G. Schnellmann

Journal:

Toxicology and Applied Pharmacology

Year:

1997

Language:

english

File:

PDF, 948 KB

english, 1997

23

Ascorbic Acid Promotes Recovery of Cellular Functions Following Toxicant-Induced Injury

Grazyna Nowak, Charleata A. Carter, Rick G. Schnellmann

Journal:

Toxicology and Applied Pharmacology

Year:

2000

Language:

english

File:

PDF, 390 KB

english, 2000

24

Analysis of the Cytotoxic Properties of Linoleic Acid Metabolites Produced by Renal and Hepatic P450s

Jeffery H. Moran, Lex A. Mitchell, J.Alyce Bradbury, Wei Qu, Darryl C. Zeldin, Rick G. Schnellmann, David F. Grant

Journal:

Toxicology and Applied Pharmacology

Year:

2000

Language:

english

File:

PDF, 137 KB

english, 2000

25

Progressive Disruption of the Plasma Membrane during Renal Proximal Tubule Cellular Injury

Jing Chen, Xiuli Liu, Lazaro J. Mandel, Rick G. Schnellmann

Journal:

Toxicology and Applied Pharmacology

Year:

2001

Language:

english

File:

PDF, 440 KB

english, 2001

26

Analysis of the Cytotoxic Properties of Linoleic Acid Metabolites Produced by Renal and Hepatic P450s: Volume 168, Number 3 (2000), pages 268–279

Jeffery H. Moran, Lex A. Mitchell, J.Alyce Bradbury, Wei Qu, Darryl C. Zeldin, Rick G. Schnellmann, David F. Grant

Journal:

Toxicology and Applied Pharmacology

Year:

2001

File:

PDF, 10 KB

2001

27

Differences in enzymatic and mechanical isolated rabbit renal proximal tubules: Comparison in long-term incubation

Denise P. Rodeheaver, Michael D. Aleo, Rick G. Schnellmann

Journal:

In Vitro Cellular & Developmental Biology - Plant

Year:

1990

Language:

english

File:

PDF, 1.34 MB

english, 1990

28

Decreasing glycolysis increases sensitivity to mitochondrial inhibition in primary cultures of renal proximal tubule cells

Richard D. Griner, Rick G. Schnellmann

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

1994

Language:

english

File:

PDF, 509 KB

english, 1994

29

The role of short chain fatty acid substrates in aerobic and glycolytic metabolism in primary cultures of renal proximal tubule cells

Richard D. Griner, Michael D. Aleo, Rick G. Schnellmann

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

1993

Language:

english

File:

PDF, 1.07 MB

english, 1993

30

Toxicity of N-(3,5-dichlorophenyl)succinimide and metabolites to rat renal proximal tubules and mitochondria

Michael D. Aleo, Gary O. Rankin, Theresa J. Cross, Rick G. Schnellmann

Journal:

Chemico-Biological Interactions

Year:

1991

Language:

english

File:

PDF, 764 KB

english, 1991

31

A mechanism of S-(1,2,3,4,4-pentachloro-1,3-butadienyl)-l-cysteine toxicity to rabbit renal proximal tubules

Rick G. Schnellmann, Edward A. Lock, Lazaro J. Mandel

Journal:

Toxicology and Applied Pharmacology

Year:

1987

Language:

english

File:

PDF, 801 KB

english, 1987

32

Mitochondrial toxicity of 2-bromohydroquinone in rabbit renal proximal tubules

Rick G. Schnellmann, Fontaine P.Q. Ewell, Maria Sgambati, Lazaro J. Mandel

Journal:

Toxicology and Applied Pharmacology

Year:

1987

Language:

english

File:

PDF, 574 KB

english, 1987

33

2-Bromohydroquinone-induced toxicity to rabbit renal proximal tubules: Evidence against oxidative stress

Rick G. Schnellmann

Journal:

Toxicology and Applied Pharmacology

Year:

1989

Language:

english

File:

PDF, 581 KB

english, 1989

34

2-Bromohydroquinone-induced toxicity to rabbit renal proximal tubules: The role of biotransformation, glutathione, and covalent binding

Rick G. Schnellmann, Terrence J. Monks, Lazaro J. Mandel, Serrine S. Lau

Journal:

Toxicology and Applied Pharmacology

Year:

1989

Language:

english

File:

PDF, 731 KB

english, 1989

35

Pentachlorobutadienyl-l-cysteine uncouples oxidative phosphorylation by dissipating the proton gradient

Rick G. Schnellmann, Theresa J. Cross, Edward A. Lock

Journal:

Toxicology and Applied Pharmacology

Year:

1989

Language:

english

File:

PDF, 703 KB

english, 1989

36

The effect of haloalkene cysteine conjugates on rat renal glutathione reductase and lipoyl dehydrogenase activities

Edward A. Lock, Rick G. Schnellmann

Journal:

Toxicology and Applied Pharmacology

Year:

1990

Language:

english

File:

PDF, 1.02 MB

english, 1990

37

The role of altered mitochondrial function in citrinin-induced toxicity to rat renal proximal tubule suspensions

Michael D. Aleo, Roger D. Wyatt, Rick G. Schnellmann

Journal:

Toxicology and Applied Pharmacology

Year:

1991

Language:

english

File:

PDF, 826 KB

english, 1991

38

Mitochondrial dysfunction is an early event in ochratoxin a but not oosporein toxicity to rat renal proximal tubules

Michael D. Aleo, Roger D. Wyatt, Rick G. Schnellmann

Journal:

Toxicology and Applied Pharmacology

Year:

1991

Language:

english

File:

PDF, 746 KB

english, 1991

39

Role of lipid peroxidation in renal proximal tubule cell death induced by haloalkene cysteine conjugates

Carlotta E. Groves, Edward A. Lock, Rick G. Schnellmann

Journal:

Toxicology and Applied Pharmacology

Year:

1991

Language:

english

File:

PDF, 774 KB

english, 1991

40

An in vitro model of renal proximal tubule cell regeneration

Sandra E. Kays, Carolyn D. Berdanier, Anne R. Swagler, Edward A. Lock, Rick G. Schnellmann

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

1993

Language:

english

File:

PDF, 598 KB

english, 1993

41

A rapid β-NADH-linked fluorescence assay for lactate dehydrogenase in cellular death

Jeffery H. Moran, Rick G. Schnellmann

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

1996

Language:

english

File:

PDF, 415 KB

english, 1996

42

Role of inducible nitric oxide synthase in mitochondrial depolarization and graft injury after transplantation of fatty livers

Qinlong Liu, Hasibur Rehman, Yasodha Krishnasamy, Venkat K. Ramshesh, Tom P. Theruvath, Kenneth D. Chavin, Rick G. Schnellmann, John J. Lemasters, Zhi Zhong

Journal:

Free Radical Biology and Medicine

Year:

2012

Language:

english

File:

PDF, 2.35 MB

english, 2012

43

Changes in gene expression in human renal proximal tubule cells exposed to low concentrations of S-(1,2-dichlorovinyl)-l-cysteine, a metabolite of trichloroethylene

Edward A. Lock, Jeremy L. Barth, Scott W. Argraves, Rick G. Schnellmann

Journal:

Toxicology and Applied Pharmacology

Year:

2006

Language:

english

File:

PDF, 682 KB

english, 2006

44

Diverse Cytoprotectants Prevent Cell Lysis and Promote Recovery of Respiration and Ion Transport

Jeffery H. Moran, Rick G. Schnellmann

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 74 KB

english, 1997

45

Depletion of Endoplasmic Reticulum Calcium Stores Protects against Hypoxia- and Mitochondrial Inhibitor-Induced Cellular Injury and Death

Shayla L. Waters, Jeremy K. Wong, Rick G. Schnellmann

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 116 KB

english, 1997

46

Perfluorooctane sulfonamide: A structurally novel uncoupler of oxidative phosphorylation

Rick G. Schnellmann, Randall O. Manning

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

1990

Language:

english

File:

PDF, 411 KB

english, 1990

47

Intracellular compartmentation of glutathione in rabbit renal proximal tubules

Rick G. Schnellmann, Lazaro J. Mandel

Journal:

Biochemical and Biophysical Research Communications

Year:

1985

Language:

english

File:

PDF, 282 KB

english, 1985

48

Metabolism of 2,2′,3,3′,6,6′-hexachlorobiphenyl and 2,2′,4,4′,5,5′-hexachlorobiphenyl by human hepatic microsomes

Rick G. Schnellmann, Charles W. Putnam, I.Glenn Sipes

Journal:

Biochemical Pharmacology

Year:

1983

Language:

english

File:

PDF, 851 KB

english, 1983

49

The hydroxylation, dechlorination, and glucuronidation of 4,4′-dichlorobiphenyl (4-DCB) by human hepatic microsomes

Rick G. Schnellmann, Robert F. Volp, Charles W. Putnam, I.Glenn Sipes

Journal:

Biochemical Pharmacology

Year:

1984

Language:

english

File:

PDF, 925 KB

english, 1984

50

Oxidants and Ca+2 induce PGC-1α degradation through calpain

Kyle A. Rasbach, Peter T. Green, Rick G. Schnellmann

Journal:

Archives of Biochemistry and Biophysics

Year:

2008

Language:

english

File:

PDF, 689 KB

english, 2008